Impaired rich-club connectivity in childhood absence epilepsy

ABSTRACT:

Introduction

Childhood absence epilepsy (CAE) is a well-known pediatric epilepsy syndrome. Recent evidence has shown the presence of a disrupted structural brain network in CAE. However, little is known about the rich-club topology. This study aimed to explore the rich-club alterations in CAE and their association with clinical characteristics.

Methods

Diffusion tensor imaging (DTI) datasets were acquired in a sample of 30 CAE patients and 31 healthy controls. A structural network was derived from DTI data for each participant using probabilistic tractography. Then, the rich-club organization was examined, and the network connections were divided into rich-club connections, feeder connections, and local connections.

Results

Our results confirmed a less dense whol

SUBMITTER: Yu Y 

PROVIDER: S-EPMC10213928 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature