Peripheral nerve repair is associated with augmented cross-tissue inflammation following vascularized composite allotransplantation.

ABSTRACT:

Introduction

Vascularized composite allotransplantation (VCA), with nerve repair/coaptation (NR) and tacrolimus (TAC) immunosuppressive therapy, is used to repair devastating traumatic injuries but is often complicated by inflammation spanning multiple tissues. We identified the parallel upregulation of transcriptional pathways involving chemokine signaling, T-cell receptor signaling, Th17, Th1, and Th2 pathways in skin and nerve tissue in complete VCA rejection compared to baseline in 7 human hand transplants and defined increasing complexity of protein-level dynamic networks involving chemokine, Th1, and Th17 pathways as a function of rejection severity in 5 of these patients. We next hypothesized that neural mechanisms may regulate the complex spatiotemporal evolution of rejecti

SUBMITTER: Shah AM 

PROVIDER: S-EPMC10213935 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature