A rising tide lifts all MBOATs: recent progress in structural and functional understanding of membrane bound O-acyltransferases.

ABSTRACT: Acylation modifications play a central role in biological and physiological processes. Across a range of biomolecules from phospholipids to triglycerides to proteins, introduction of a hydrophobic acyl chain can dramatically alter the biological function and cellular localization of these substrates. Amongst the enzymes catalyzing these modifications, the membrane bound O-acyltransferase (MBOAT) family occupies an intriguing position as the combined substrate selectivities of the various family members span all three classes of these biomolecules. MBOAT-dependent substrates are linked to a wide range of health conditions including metabolic disease, cancer, and neurodegenerative disease. Like many integral membrane proteins, these enzymes have presented challenges to investigation d

SUBMITTER: Pierce MR 

PROVIDER: S-EPMC10213974 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature