Respiratory therapies for Amyotrophic Lateral Sclerosis: A state of the art review.

ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition noteworthy for upper and lower motor neuron death. Involvement of respiratory motor neuron pools leads to progressive pathology. These impairments include decreases in neural activation and muscle coordination, progressive airway obstruction, weakened airway defenses, restrictive lung disease, increased risk of pulmonary infections, and weakness and atrophy of respiratory muscles. These neural, airway, pulmonary, and neuromuscular changes deteriorate integrated respiratory-related functions including sleep, cough, swallowing, and breathing. Ultimately, respiratory complications account for a large portion of morbidity and mortality in ALS. This state-of-the-art review highlights applications of respiratory therapies for A

SUBMITTER: Sales de Campos P 

PROVIDER: S-EPMC10214054 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature