Ginsenosides Rc, as a novel SIRT6 activator, protects mice against high fat diet induced NAFLD.

ABSTRACT:

Background

Hepatic lipid disorder impaired mitochondrial homeostasis and intracellular redox balance, triggering development of non-alcohol fatty liver disease (NAFLD), while effective therapeutic approach remains inadequate. Ginsenosides Rc has been reported to maintain glucose balance in adipose tissue, while its role in regulating lipid metabolism remain vacant. Thus, we investigated the function and mechanism of ginsenosides Rc in defending high fat diet (HFD)-induced NAFLD.

Methods

Mice primary hepatocytes (MPHs) challenged with oleic acid & palmitic acid were used to test the effects of ginsenosides Rc on intracellular lipid metabolism. RNAseq and molecular docking study were performed to explore potential targets of ginsenosides Rc in defending lipid deposition. Wild

SUBMITTER: Yang Z 

PROVIDER: S-EPMC10214131 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature