Entropic control of the free-energy landscape of an archetypal biomolecular machine.

ABSTRACT: Biomolecular machines are complex macromolecular assemblies that utilize thermal and chemical energy to perform essential, multistep, cellular processes. Despite possessing different architectures and functions, an essential feature of the mechanisms of action of all such machines is that they require dynamic rearrangements of structural components. Surprisingly, biomolecular machines generally possess only a limited set of such motions, suggesting that these dynamics must be repurposed to drive different mechanistic steps. Although ligands that interact with these machines are known to drive such repurposing, the physical and structural mechanisms through which ligands achieve this remain unknown. Using temperature-dependent, single-molecule measurements analyzed with a time-resolution-en

SUBMITTER: Ray KK 

PROVIDER: S-EPMC10214133 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature