The membrane electric field regulates the PIP₂-binding site to gate the KCNQ1 channel.

ABSTRACT: Voltage-dependent ion channels underlie the propagation of action potentials and other forms of electrical activity in cells. In these proteins, voltage sensor domains (VSDs) regulate opening and closing of the pore through the displacement of their positive-charged S4 helix in response to the membrane voltage. The movement of S4 at hyperpolarizing membrane voltages in some channels is thought to directly clamp the pore shut through the S4-S5 linker helix. The KCNQ1 channel (also known as K_v7.1), which is important for heart rhythm, is regulated not only by membrane voltage but also by the signaling lipid phosphatidylinositol 4,5-bisphosphate (PIP₂). KCNQ1 requires PIP₂ to open and to couple the movement of S4 in the VSD to the pore. To understand the mecha

SUBMITTER: Mandala VS 

PROVIDER: S-EPMC10214144 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature