Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC10214149 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Liu Siyuan S Akula Nirmala N Reardon Paul K PK Russ Jill J Torres Erin E Clasen Liv S LS Blumenthal Jonathan J Lalonde Francois F McMahon Francis J FJ Szele Francis F Disteche Christine M CM Cader M Zameel MZ Raznahan Armin A
Proceedings of the National Academy of Sciences of the United States of America 20230516 21
Aneuploidy syndromes impact multiple organ systems but understanding of tissue-specific aneuploidy effects remains limited-especially for the comparison between peripheral tissues and relatively inaccessible tissues like brain. Here, we address this gap in knowledge by studying the transcriptomic effects of chromosome X, Y, and 21 aneuploidies in lymphoblastoid cell lines, fibroblasts and iPSC-derived neuronal cells (LCLs, FCL, and iNs, respectively). We root our analyses in sex chromosome aneup ...[more]