COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis.

ABSTRACT: Occurrence of hyperglycemia upon infection is associated with worse clinical outcome in COVID-19 patients. However, it is still unknown whether SARS-CoV-2 directly triggers hyperglycemia. Herein, we interrogated whether and how SARS-CoV-2 causes hyperglycemia by infecting hepatocytes and increasing glucose production. We performed a retrospective cohort study including patients that were admitted at a hospital with suspicion of COVID-19. Clinical and laboratory data were collected from the chart records and daily blood glucose values were analyzed to test the hypothesis on whether COVID-19 was independently associated with hyperglycemia. Blood glucose was collected from a subgroup of nondiabetic patients to assess pancreatic hormones. Postmortem liver biopsies were collected to asse

SUBMITTER: Barreto EA 

PROVIDER: S-EPMC10214153 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature