Activation of P53 pathway contributes to Xenopus hybrid inviability.

ABSTRACT: Hybrid incompatibility as a kind of reproductive isolation contributes to speciation. The nucleocytoplasmic incompatibility between Xenopus tropicalis eggs and Xenopus laevis sperm (t_e×l_s) leads to specific loss of paternal chromosomes 3L and 4L. The hybrids die before gastrulation, of which the lethal causes remain largely unclear. Here, we show that the activation of the tumor suppressor protein P53 at late blastula stage contributes to this early lethality. We find that in stage 9 embryos, P53-binding motif is the most enriched one in the up-regulated Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq) peaks between t_e×l_s and wild-type X. tropicalis controls, wh

SUBMITTER: Shi Z 

PROVIDER: S-EPMC10214167 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature