Optimally Configured Optical Fiber Near-Field Enhanced Plasmonic Resonance Immunoprobe for the Detection of Alpha-Fetoprotein.

ABSTRACT: The detection of trace biomarkers is an important supplementary approach for early screening and diagnoses of tumors. An optical fiber near-field enhanced plasmonic resonance immunoprobe is developed for the detection of the hepatocellular carcinoma biomarker, i.e., the alpha-fetoprotein. Generic principles based on dispersion models and finite element analysis (FEA) models are developed to realize the optimized configuration of spectral characteristics of the immunoprobe. Dispersion models provide theoretical guidance for the design of the multilayer sensing structure from the perspective of the ray optics theory. FEA models provide theoretical guidance for the selection of coating materials from the perspective of the self-defined dielectric constant ratio, i.e., the ratio of the real pa

SUBMITTER: Jing J 

PROVIDER: S-EPMC10214261 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature