Efficacy of vitamin D₃ supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomised controlled trials.

ABSTRACT: To evaluate the effect of vitamin D₃ supplementation on cancer mortality in the general population and on prognosis in cancer patients, a systematic review and meta-analysis of randomised, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted. Overall, 14 RCTs with a total of 104,727 participants (2015 cancer deaths) were identified and 7 RCTs, including 90 % of all study participants (n = 94,068), could be included in the IPD meta-analyses. The main meta-analysis of the 14 RCTs yielded a statistically non-significant reduction in cancer mortality by 6 % (risk ratio (RR) [95%-confidence interval (95%CI)]: 0.94 [0.86-1.02]). Subgroup analyses revealed a 12 % lower cancer mortality in the vitamin D₃ group compared with the placebo group in 10

SUBMITTER: Kuznia S 

PROVIDER: S-EPMC10214278 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature