Conjunctival and Lingual mucosal neuromas without multiple endocrine neoplasia type 2B.

ABSTRACT:

Purpose

To report a patient with conjunctival and buccal neuromas and enlarged corneal nerves without Multiple Endocrine Neoplasia 2B (MEN2B).

Observations

A 28-year-old female presented with progressively enlarging bilateral limbal conjunctival growths. Slit lamp examination was notable for enlarged corneal nerves and well-circumscribed gelatinous subepithelial limbal nodules. Systemic examination revealed similar lesions on the tongue. Conjunctival biopsy demonstrated a mucosal neuroma. The patient underwent endocrine workup for MEN2B and genetic testing for the RET-proto oncogene mutations, all of which were negative.

Conclusions and importance

The findings in our patient may be compatible with pure mucosal neuroma syndrome. The pattern of conjunctival neuro

SUBMITTER: Shoshany TN 

PROVIDER: S-EPMC10214301 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature