Energy Partitioning in Multicomponent Nanoscintillators for Enhanced Localized Radiotherapy.

ABSTRACT: Multicomponent nanomaterials consisting of dense scintillating particles functionalized by or embedding optically active conjugated photosensitizers (PSs) for cytotoxic reactive oxygen species (ROS) have been proposed in the last decade as coadjuvant agents for radiotherapy of cancer. They have been designed to make scintillation-activated sensitizers for ROS production in an aqueous environment under exposure to ionizing radiations. However, a detailed understanding of the global energy partitioning process occurring during the scintillation is still missing, in particular regarding the role of the non-radiative energy transfer between the nanoscintillator and the conjugated moieties which is usually considered crucial for the activation of PSs and therefore pivotal to enhance the therape

SUBMITTER: Secchi V 

PROVIDER: S-EPMC10214376 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature