Exploration behavior after reversals is predicted by STN-GPe synaptic plasticity in a basal ganglia model.

ABSTRACT: Humans can quickly adapt their behavior to changes in the environment. Classical reversal learning tasks mainly measure how well participants can disengage from a previously successful behavior but not how alternative responses are explored. Here, we propose a novel 5-choice reversal learning task with alternating position-reward contingencies to study exploration behavior after a reversal. We compare human exploratory saccade behavior with a prediction obtained from a neuro-computational model of the basal ganglia. A new synaptic plasticity rule for learning the connectivity between the subthalamic nucleus (STN) and external globus pallidus (GPe) results in exploration biases to previously rewarded positions. The model simulations and human data both show that during experimental experien

SUBMITTER: Maith O 

PROVIDER: S-EPMC10214406 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature