Multicentre genetic diversity study of carbapenem-resistant Enterobacterales: predominance of untypeable pUVA-like bla_KPC bearing plasmids.

ABSTRACT:

Objectives

Carbapenem-resistant Enterobacterales (CRE) are an urgent public health threat. A better understanding of the molecular epidemiology and transmission dynamics of CRE is necessary to limit their dissemination within healthcare settings. We sought to investigate the mechanisms of resistance and spread of CRE within multiple hospitals in Maryland.

Methods

From 2016 to 2018, all CRE were collected from any specimen source from The Johns Hopkins Medical Institutions. The isolates were further characterized using both phenotypic and genotypic approaches, including short- and/or long-read WGS.

Results

From 2016 to 2018, 302 of 40 908 (0.7%) unique Enterobacterales isolates were identified as CRE. Of CRE, 142 (47%) were carbapenemase-producing CRE with KPC (80.3%)

SUBMITTER: Simner PJ 

PROVIDER: S-EPMC10214462 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature