Alveolar-arterial oxygen gradient nonlinearly impacts the 28-day mortality of patients with sepsis: Secondary data mining based on the MIMIC-IV database.

ABSTRACT:

Objective

Lung is often implicated in sepsis, resulting in acute respiratory distress syndrome (ARDS). The alveolar-arterial oxygen gradient [D(A-a)O₂ ] reflects lung diffusing capacity, which is usually compromised in ARDS. But whether D(A-a)O₂ impacts the prognosis of patients with sepsis remains to be explored. Our study aims to investigate the association between D(A-a)O₂ and 28-day mortality in patients with sepsis using a large sample, multicenter Medical Information Mart for Intensive Care (MIMIC)-IV database.

Methods

We extracted a data of 35 010 patients with sepsis from the retrospective cohort MIMIC-IV database, by which the independent effects of D(A-a)O₂ on 28-day death risk was investigated, with D(A-a)O₂ a

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10214571 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature