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ABSTRACT: Introduction
This study aims to explore the predictive value of CT radiomics and clinical characteristics for treatment response in COVID-19 patients.Methods
Data were collected from clinical/auxiliary examinations and follow-ups of COVID-19 patients. Whole lung radiomics feature extraction was performed at baseline chest CT. Radiomics, clinical, and combined features (nomogram) were evaluated for predicting treatment response.Results
Among 36 COVID-19 patients, mild, common, severe, and critical disease symptoms were found in 1, 21, 13, and 1 of them, respectively. Twenty-five (1 mild, 18 common, and 6 severe) patients showed a good response to treatment and 11 poor/fair responses. The clinical classification (p = 0.025) and serum creatinine (p = 0.010) on admission and small area emphasis (p = 0.036) from radiomics analysis significantly differed between the two groups. Predictive models were constructed based on the radiomics, clinical features, and nomogram showing an area under the curve of 0.651, 0.836, and 0.869, respectively. The nomogram achieved good calibration.Conclusion
This new, non-invasive, and low-cost prediction model that combines the radiomics and clinical features is useful for identifying COVID-19 patients who may not respond well to treatment.
SUBMITTER: Huang G
PROVIDER: S-EPMC10214574 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Huang Gang G Hui Zhongyi Z Ren Jialiang J Liu Ruifang R Cui Yaqiong Y Ma Ying Y Han Yalan Y Zhao Zehao Z Lv Suzhen S Zhou Xing X Chen Lijun L Bao Shisan S Zhao Lianping L
The clinical respiratory journal 20230321 5
<h4>Introduction</h4>This study aims to explore the predictive value of CT radiomics and clinical characteristics for treatment response in COVID-19 patients.<h4>Methods</h4>Data were collected from clinical/auxiliary examinations and follow-ups of COVID-19 patients. Whole lung radiomics feature extraction was performed at baseline chest CT. Radiomics, clinical, and combined features (nomogram) were evaluated for predicting treatment response.<h4>Results</h4>Among 36 COVID-19 patients, mild, com ...[more]