MSCs' conditioned media cytokine and growth factor profiles and their impact on macrophage polarization.

ABSTRACT:

Background

There is a growing body of evidence that multipotent mesenchymal stromal cells' (MSCs') remarkable therapeutic potential is attributed not only to their differentiation and regenerative capacity, but also to the paracrine effect, underlying their immunomodulatory properties. MSCs' secretome (i.e., cytokines, growth factors, and extracellular vesicles) is therefore increasingly discussed in the context of their ability to modulate inflammatory response and promote regeneration. There is evidence that 2D or 3D culturing conditions have an impact on the cells' secretome, and here we aimed to compare the secretion of cytokines and growth factors in human MSCs from different sources cultured in 2D and 3D conditions and assess their effect on human macrophages polarization in

SUBMITTER: Peshkova M 

PROVIDER: S-EPMC10214600 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature