Associations Between Loneliness and Cognitive Resilience to Neuropathology in Older Adults.

ABSTRACT:

Objectives

Loneliness in the aging population is associated with decreased cognitive function and increased neuropathology; less is understood about the association of loneliness and cognitive resilience (CR), defined as the discordance between a person's actual and expected cognition given their neuropathology. Here we assess the effect of loneliness and change in loneliness on CR at end of life and across older adulthood.

Methods

Data were combined from 2 longitudinal studies of older adults. CR proximate to death (CRlast_level) and across time (CRslope) was obtained by independently regressing global cognition and change in cognition onto multiple neuropathology indicators and extracting the resulting residuals. We used a series of simple linear regression models to asses

SUBMITTER: Jackson KL 

PROVIDER: S-EPMC10214654 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature