Reactive Bergmann glia play a central role in spinocerebellar ataxia inflammation via the JNK pathway.

ABSTRACT: The spinocerebellar ataxias (SCAs) are devastating neurological diseases characterized by progressive cerebellar incoordination. While neurons bear the brunt of the pathology, a growing body of evidence suggests that glial cells are also affected. It has, however, been difficult to understand the role of glia, given the diversity of subtypes, each with their individual contributions to neuronal health. Using human SCA autopsy samples we have discovered that Bergmann glia-the radial glia of the cerebellum, which form intimate functional connections with cerebellar Purkinje neurons-display inflammatory JNK-dependent c-Jun phosphorylation. This phosphorylation defines a signaling pathway not observed in other activated glial populations, providing an opportunity to isolate the role of Bergman

SUBMITTER: Edamakanti CR 

PROVIDER: S-EPMC10214658 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature