Anatomical organization of temporally correlated neural calcium activity in the hippocampal CA1 region.

ABSTRACT: Hippocampal CA1 neuronal ensembles generate sequential patterns of firing activity that contribute to episodic memory formation and spatial cognition. Here we used in vivo calcium imaging to record neural ensemble activities in mouse hippocampal CA1 and identified CA1 excitatory neuron sub-populations whose members are active across the same second-long period of time. We identified groups of hippocampal neurons sharing temporally correlated neural calcium activity during behavioral exploration and found that they also organized as clusters in anatomical space. Such clusters vary in membership and activity dynamics with respect to movement in different environments, but also appear during immobility in the dark suggesting an internal dynamic. The strong covariance between dynamics a

SUBMITTER: Chen L 

PROVIDER: S-EPMC10214731 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature