Relationship between IDH1/2 and TERT promoter mutation and the prognosis of human glioma patients.

ABSTRACT:

Objective

To investigate the relationship between isocitrate dehydrogenase (IDH) 1/2 mutation, telomerase reverse transcriptase (TERT) gene promoter mutation and the prognosis of human glioma patients.

Methods

One hundred fifteen patients with human glioma, treated surgically in The First Affiliated Hospital of Hebei North University from January 2019 to January 2020, were included. All patients were followed up until January 31, 2022. The mutations of IDH1/2 and TERT promoter were analyzed, and risk factors affecting survival of the patients with glioma were assessed.

Results

IDH1 gene mutation occurred in 82 cases, IDH2 gene mutation occurred in five cases and TERT promoter mutation occurred in 54 cases. Univariate analysis showed that tumor WHO grade, resection ran

SUBMITTER: Liu X 

PROVIDER: S-EPMC10214788 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature