Fluid Overload Precedes and Masks Cryptic Kidney Injury in Pediatric Acute Respiratory Distress Syndrome.

ABSTRACT:

Objectives

Given the complex interrelatedness of fluid overload (FO), creatinine, acute kidney injury (AKI), and clinical outcomes, the association of AKI with poor outcomes in critically ill children may be underestimated due to definitions used. We aimed to disentangle these temporal relationships in a large cohort of children with acute respiratory distress syndrome (ARDS).

Design

Retrospective cohort study.

Setting

Quaternary care PICU.

Patients

Seven hundred twenty intubated children with ARDS between 2011 and 2019.

Interventions

None.

Measurements and main results

Daily fluid balance, urine output (UOP), and creatinine for days 1-7 of ARDS were retrospectively abstracted. A subset of patients had angiopoietin 2 (ANGPT2) quantified on days 1,

SUBMITTER: Dixon CG 

PROVIDER: S-EPMC10214878 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature