Demonstration of fast multi-slice quasi-steady-state chemical exchange saturation transfer (QUASS CEST) human brain imaging at 3T.

ABSTRACT:

Purpose

To combine multi-slice chemical exchange saturation transfer (CEST) imaging with quasi-steady-state (QUASS) processing and demonstrate the feasibility of fast QUASS CEST MRI at 3T.

Methods

Fast multi-slice echo planar imaging (EPI) CEST imaging was developed with concatenated slice acquisition after single radiofrequency irradiation. The multi-slice CEST signal evolution was described by the spin-lock relaxation during saturation duration (T_s ) and longitudinal relaxation during the relaxation delay time (T_d ) and post-label delay (PLD), from which the QUASS CEST was generalized to fast multi-slice acquisition. In addition, numerical simulations, phantom, and normal human subjects scans were performed to compare the conventional apparent and QUA

SUBMITTER: Kim H 

PROVIDER: S-EPMC10214900 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature