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Synthesis of 4-aryl-3,4-dihydrocoumarins and 4-aryl-4H-chromenes via Er(OTf)₃-catalyzed cascade reactions of p-quinone methides with 1,3-dicarbonyl compounds.

ABSTRACT: The Er(OTf)₃-catalyzed cascade cyclization reaction of para-quinone methides (p-QMs) with various 1,3-dicarbonyl compounds has been developed, which efficiently constructed a series of versatile 4-aryl-3,4-dihydrocoumarins and 4-aryl-4H-chromenes. Herein, we not only propose a novel cyclization strategy of p-QMs, but also provide an easy access to structurally diverse coumarins and chromenes.

SUBMITTER: Bao X

PROVIDER: S-EPMC10214920 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Synthesis of 4-aryl-3,4-dihydrocoumarins and 4-aryl-4H-chromenes via Er(OTf)3-catalyzed cascade reactions of p-quinone methides with 1,3-dicarbonyl compounds.

Bao Xiaobo X Yu Wei W Wang Lilin L Dong Xu X Wang Guoli G Chen Weilin W Li Fei F Chen Dongyin D

RSC advances 20230526 23

The Er(OTf)3-catalyzed cascade cyclization reaction of para-quinone methides (p-QMs) with various 1,3-dicarbonyl compounds has been developed, which efficiently constructed a series of versatile 4-aryl-3,4-dihydrocoumarins and 4-aryl-4H-chromenes. Herein, we not only propose a novel cyclization strategy of p-QMs, but also provide an easy access to structurally diverse coumarins and chromenes. ...[more]

PMID: 37250229

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