DAP3-mediated cell cycle regulation and its association with radioresistance in human lung adenocarcinoma cell lines.

ABSTRACT: Mitochondria play important roles in the cellular response to various types of stress, including that triggered by ionizing radiation. We have previously reported that the mitochondrial ribosomal protein death-associated protein 3 (DAP3) regulates the radioresistance of human lung adenocarcinoma (LUAD) cell lines A549 and H1299. However, the underlying mechanism of this regulation remains to be elucidated. To this end, we have herein investigated the role of DAP3 in the cell cycle regulation after irradiation. Notably, the DAP3 knockdown attenuated the radiation-induced increase of the G2/M cell population. Furthermore, western blotting analysis has revealed that the DAP3 knockdown decreased the expression of proteins related to the G2/M arrest, such as those of the phosphorylated cdc2 (Ty

SUBMITTER: Sato Y 

PROVIDER: S-EPMC10214994 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature