Traumatic Brain Injury Alters Cerebral Concentrations and Redox States of Coenzymes Q₉ and Q₁₀ in the Rat.

ABSTRACT: To date, there is no information on the effect of TBI on the changes in brain CoQ levels and possible variations in its redox state. In this study, we induced graded TBIs (mild TBI, mTBI and severe TBI, sTBI) in male rats, using the weight-drop closed-head impact acceleration model of trauma. At 7 days post-injury, CoQ₉, CoQ₁₀ and α-tocopherol were measured by HPLC in brain extracts of the injured rats, as well as in those of a group of control sham-operated rats. In the controls, about the 69% of total CoQ was in the form of CoQ₉ and the oxidized/reduced ratios of CoQ₉ and CoQ₁₀ were, respectively, 1.05 ± 0.07 and 1.42 ± 0.17. No significant changes in these values were observed in rats experiencing mTBI. Conversely, in the brains of

SUBMITTER: Lazzarino G 

PROVIDER: S-EPMC10215158 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature