Comparative Genomics of Pseudomonas aeruginosa Strains Isolated from Different Ecological Niches.

ABSTRACT: The Pseudomonas aeruginosa genome can change to adapt to different ecological niches. We compared four genomes from a Mexican hospital and 59 genomes from GenBank from different niches, such as urine, sputum, and environmental. The ST analysis showed that high-risk STs (ST235, ST773, and ST27) were present in the genomes of the three niches from GenBank, and the STs of Mexican genomes (ST167, ST2731, and ST549) differed from the GenBank genomes. Phylogenetic analysis showed that the genomes were clustering according to their ST and not their niche. When analyzing the genomic content, we observed that environmental genomes had genes involved in adapting to the environment not found in the clinics and that their mechanisms of resistance were mutations in antibiotic resistance-related

SUBMITTER: Gomez-Martinez J 

PROVIDER: S-EPMC10215170 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature