Tumor Microenvironment and Glioblastoma Cell Interplay as Promoters of Therapeutic Resistance.

ABSTRACT: The invasive nature of glioblastoma is problematic in a radical surgery approach and can be responsible for tumor recurrence. In order to create new therapeutic strategies, it is imperative to have a better understanding of the mechanisms behind tumor growth and invasion. The continuous cross-talk between glioma stem cells (GSCs) and the tumor microenvironment (TME) contributes to disease progression, which renders research in this field difficult and challenging. The main aim of the review was to assess the different possible mechanisms that could explain resistance to treatment promoted by TME and GSCs in glioblastoma, including the role of M2 macrophages, micro RNAs (miRNAs), and long non-coding RNAs (lncRNAs) from exosomes from the TME. A systematic review of the literature on the role

SUBMITTER: Agosti E 

PROVIDER: S-EPMC10215375 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature