Identification of intestinal microbiome associated with lymph-vascular invasion in colorectal cancer patients and predictive label construction.

ABSTRACT:

Objective

To identify differences between the composition, abundance, and biological function of the intestinal microbiome of patients with and without lymph-vascular invasion (LVI) colorectal cancer (CRC) and to construct predictive labels to support accurate assessment of LVI in CRC.

Method

134 CRC patients were included, which were divided into two groups according to the presence or absence of LVI, and their intestinal microbiomes were sequenced by 16SrRNA and analyzed for differences. The transcriptome sequencing data of 9 CRC patients were transformed into immune cells abundance matrix by CIBERSORT algorithm, and the correlation among LVI-associated differential intestinal microbiomes, immune cells, immune-related genes and LVI-associated differential GO items and KEGG

SUBMITTER: Chen C 

PROVIDER: S-EPMC10215531 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature