Characterization of bla_KPC-2 and bla_NDM-1 Plasmids of a K. pneumoniae ST11 Outbreak Clone.

ABSTRACT: The most common resistance mechanism to carbapenems is the production of carbapenemases. In 2021, the Pan American Health Organization warned of the emergence and increase in new carbapenemase combinations in Enterobacterales in Latin America. In this study, we characterized four Klebsiella pneumoniae isolates harboring bla_KPC and bla_NDM from an outbreak during the COVID-19 pandemic in a Brazilian hospital. We assessed their plasmids' transference ability, fitness effects, and relative copy number in different hosts. The K. pneumoniae BHKPC93 and BHKPC104 strains were selected for whole genome sequencing (WGS) based on their pulsed-field gel electrophoresis profile. The WGS revealed that both isolates belong to ST11, and 20 resistanc

SUBMITTER: Boralli CMDS 

PROVIDER: S-EPMC10215860 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature