Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of Blueberries.

ABSTRACT: Epidemiological studies have shown associations between polyphenol-rich fruit intake and bone health, and preclinical studies have shown that blueberries improve bone health. To determine the genotype and dose of blueberries that are effective in ameliorating age-related bone loss, a multi-institutional team of investigators performed in vitro, preclinical, and clinical studies on blueberry varieties that differed in flavonoid profiles. Principal component analysis was used to select blueberry genotypes that varied in anthocyanin profiles. Total phenolic content did not predict the bioavailability of polyphenolic compounds in rats. A range in bioavailability was observed in individual polyphenolic compounds across genotypes. Both alpha and beta diversity analyses indicated that gut microbi

SUBMITTER: Weaver CM 

PROVIDER: S-EPMC10215964 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature