Adverse Childhood Experiences, Inflammation, and Depressive Symptoms in Late Life: A Population-Based Study.

ABSTRACT:

Objectives

This study investigated the association and dose-response relationship between adverse childhood experiences (ACEs) and depressive symptoms in late life and explored the mediating roles of inflammatory markers in the ACEs-depressive symptom association among Chinese older adults.

Methods

This study was conducted using 2014 life history survey data and 2015 follow-up data from the China Health and Retirement Longitudinal Study. Data on ACEs and depression, inflammatory markers of high-sensitivity C-reactive protein (CRP), and white blood cell were collected. The association between ACEs and depressive symptoms was examined using logistic regression, and the mediation effects of inflammatory markers were evaluated.

Results

A total of 6,518 individuals over 60

SUBMITTER: Li C 

PROVIDER: S-EPMC10215978 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature