Altered Purinergic Signaling in Neurodevelopmental Disorders: Focus on P2 Receptors.

ABSTRACT: With the umbrella term 'neurodevelopmental disorders' (NDDs) we refer to a plethora of congenital pathological conditions generally connected with cognitive, social behavior, and sensory/motor alterations. Among the possible causes, gestational and perinatal insults have been demonstrated to interfere with the physiological processes necessary for the proper development of fetal brain cytoarchitecture and functionality. In recent years, several genetic disorders caused by mutations in key enzymes involved in purine metabolism have been associated with autism-like behavioral outcomes. Further analysis revealed dysregulated purine and pyrimidine levels in the biofluids of subjects with other NDDs. Moreover, the pharmacological blockade of specific purinergic pathways reversed the cognitive a

SUBMITTER: Boccazzi M 

PROVIDER: S-EPMC10216121 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature