Neural Responses to a Working Memory Task in Acute Depressed and Remitted Phases in Bipolar Patients.

ABSTRACT: (1) Cognitive impairments such as working memory (WM) deficits are amongst the most common dysfunctions characterizing bipolar disorder (BD) patients, severely contributing to functional impairment. We aimed to investigate WM performance and associated brain activation during the acute phase of BD and to observe changes in the same patients during remission. (2) Frontal brain activation was recorded using functional near-infrared spectroscopy (fNIRS) during n-back task conditions (one-back, two-back and three-back) in BD patients in their acute depressive (n = 32) and remitted (n = 15) phases as well as in healthy controls (n = 30). (3) Comparison of BD patients during their acute phase with controls showed a trend (p = 0.08) towards lower dorsolateral prefronta

SUBMITTER: Kopf J 

PROVIDER: S-EPMC10216136 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature