Targeting Hypoxia-Inducible Factor-1α for the Management of Hepatocellular Carcinoma

ABSTRACT:

Simple Summary

Hypoxia, or low oxygen levels within tumor tissue, presents a significant challenge for the management of hepatocellular carcinoma (HCC). Hypoxic microenvironments can induce changes in gene expression and cellular metabolism that promote tumor growth, metastasis, and resistance to chemotherapy and radiation therapy, making the cancer cells more aggressive and difficult to treat. Targeting hypoxia in HCC has emerged as a promising strategy for improving treatment outcomes. The aim of this review is to summarize the current knowledge on the role and biochemical pathways of hypoxia in the progression of HCC. This review also discusses the potential therapeutic options for targeting hypoxia for the management of HCC.

Abstract

Hypoxia-inducible factor 1 alpha (

SUBMITTER: Huynh K 

PROVIDER: S-EPMC10216171 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature