Association of Long Noncoding RNA Expression Signatures with Stress-Induced Myocardial Perfusion Defects.

ABSTRACT: Stress-induced myocardial perfusion defects found in dipyridamole-thallium-201 single-photon emission computed tomography imaging may indicate vascular perfusion abnormalities and risk of obstructive or nonobstructive coronary heart disease. Besides nuclear imaging and subsequent coronary angiography (CAG), no blood test can indicate whether dysregulated homeostasis is associated with stress-induced myocardial perfusion defects. This study investigated the expression signature of long noncoding RNAs (lncRNAs) and genes involved in vascular inflammation and stress response in the blood of patients with stress-induced myocardial perfusion abnormalities (n = 27). The results revealed an expression signature consisting of the upregulation of RMRP (p < 0.01) and downregulat

SUBMITTER: Chang YC 

PROVIDER: S-EPMC10216234 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature