Acute Myeloid Leukemia Stem Cells in Minimal/Measurable Residual Disease Detection.

ABSTRACT: Acute myeloid leukemia (AML) is a hematological malignancy characterized by an abundance of incompletely matured or immature clonally derived hematopoietic precursors called leukemic blasts. Rare leukemia stem cells (LSCs) that can self-renew as well as give rise to leukemic progenitors comprising the bulk of leukemic blasts are considered the cellular reservoir of disease initiation and maintenance. LSCs are widely thought to be relatively resistant as well as adaptive to chemotherapy and can cause disease relapse. Therefore, it is imperative to understand the molecular bases of LSC forms and functions during different stages of disease progression, so we can more accurately identify these cells and design therapies to target them. Irrespective of the morphological, cytogenetic, and cellu

SUBMITTER: Srinivasan Rajsri K 

PROVIDER: S-EPMC10216329 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature