Pharmacological Potential of 3-Benzazepines in NMDAR-Linked Pathophysiological Processes.

ABSTRACT: The number of N-Methyl-D-aspartate receptor (NMDAR) linked neurodegenerative diseases such as Alzheimer's disease and dementia is constantly increasing. This is partly due to demographic change and presents new challenges to societies. To date, there are no effective treatment options. Current medications are nonselective and can lead to unwanted side effects in patients. A promising therapeutic approach is the targeted inhibition of NMDARs in the brain. NMDARs containing different subunits and splice variants display different physiological properties and play a crucial role in learning and memory, as well as in inflammatory or injury processes. They become overactivated during the course of the disease, leading to nerve cell death. Until now, there has been a lack of understanding

SUBMITTER: Ritter N 

PROVIDER: S-EPMC10216354 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature