TRPM4 Blocking Antibody Protects Cerebral Vasculature in Delayed Stroke Reperfusion.

ABSTRACT: Reperfusion therapy for acute ischemic stroke aims to restore the blood flow of occluded blood vessels. However, successful recanalization is often associated with disruption of the blood-brain barrier, leading to reperfusion injury. Delayed recanalization increases the risk of severe reperfusion injury, including severe cerebral edema and hemorrhagic transformation. The TRPM4-blocking antibody M4P has been shown to alleviate reperfusion injury and improve functional outcomes in animal models of early stroke reperfusion. In this study, we examined the role of M4P in a clinically relevant rat model of delayed stroke reperfusion in which the left middle cerebral artery was occluded for 7 h. To mimic the clinical scenario, M4P or control IgG was administered 1 h before recanalization. Immunos

SUBMITTER: Chen B 

PROVIDER: S-EPMC10216476 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature