A Newly Developed Method-Based Xanthine Oxidoreductase Activities in Various Human Liver Diseases.

ABSTRACT: Studies evaluating xanthine oxidoreductase (XOR) activities in comprehensive liver diseases are scarce, and different etiologies have previously been combined in groups for comparison. To accurately evaluate XOR activities in liver diseases, the plasma XOR activities in etiology-based comprehensive liver diseases were measured using a novel, sensitive, and accurate assay that is a combination of liquid chromatography and triple quadrupole mass spectrometry to detect [¹³C₂, ¹⁵N₂]uric acid using [¹³C₂, ¹⁵N₂]xanthine as a substrate. We also mainly evaluated the association between the plasma XOR activities and parameters of liver tests, purine metabolism-associated markers, oxidative stress markers, and an

SUBMITTER: Sato K 

PROVIDER: S-EPMC10216503 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature