Head-to-Head Intra-Individual Comparison of Biodistribution and Tumor Uptake of [¹⁸F]FAPI-74 with [¹⁸F]FDG in Patients with PDAC: A Prospective Exploratory Study.

ABSTRACT:

Background

Radiolabeled fibroblast activation protein (FAP) ligands, a novel class of tracers for PET/CT imaging, have demonstrated very promising results in various oncological, as well as in some benign, diseases with long-term potential to supplant the current pan-cancer agent [¹⁸F]FDG in some cancer types. Pancreatic ductal carcinoma (PDAC) belongs to the group of epithelial malignancies with a strong so-called "desmoplastic reaction", leading to a prominent tumor stroma with cancer-associated fibroblasts that exhibit a marked overexpression of fibroblast activation protein (FAP). The first clinical experiences in PDAC with ⁶⁸Ga-labeled FAP ligands suggested superior sensitivity to [¹⁸F]FDG. However, there is limited data with ¹⁸F-lab

SUBMITTER: Novruzov E 

PROVIDER: S-EPMC10216510 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature