TCGA Expression Analyses of 10 Carcinoma Types Reveal Clinically Significant Racial Differences.

ABSTRACT: Epidemiological studies reveal disparities in cancer incidence and outcome rates between racial groups in the United States. In our study, we investigated molecular differences between racial groups in 10 carcinoma types. We used publicly available data from The Cancer Genome Atlas to identify patterns of differential gene expression in tumor samples obtained from 4112 White, Black/African American, and Asian patients. We identified race-dependent expression of numerous genes whose mRNA transcript levels were significantly correlated with patients' survival. Only a small subset of these genes was differentially expressed in multiple carcinomas, including genes involved in cell cycle progression such as CCNB1, CCNE1, CCNE2, and FOXM1. In contrast, most other gene

SUBMITTER: Lei B 

PROVIDER: S-EPMC10216530 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature