Analysis of CDR3 Sequences from T-Cell Receptor β in Acute Respiratory Distress Syndrome

ABSTRACT: Acute Respiratory Distress Syndrome (ARDS) is an illness that typically develops in people who are significantly ill or have serious injuries. ARDS is characterized by fluid build-up that occurs in the alveoli. T-cells are implicated as playing a role in the modulation of the aberrant response leading to excessive tissue damage and, eventually, ARDS. Complementarity Determining Region 3 (CDR3) sequences derived from T-cells are key players in the adaptive immune response. This response is governed by an elaborate specificity for distinct molecules and the ability to recognize and vigorously respond to repeated exposures to the same molecules. Most of the diversity in T-cell receptors (TCRs) is contained in the CDR3 regions of the heterodimeric cell-surface receptors. For this study, we emp

SUBMITTER: Hey S 

PROVIDER: S-EPMC10216544 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature