The Cytokine, Chemokine, and Growth Factor Network of Prenatal Depression.

ABSTRACT:

Background

Neuro-immune pathways are engaged in antenatal and postpartum depression.

Aims

To determine if immune profiles influence the severity of prenatal depression above and beyond the effects of adverse childhood experiences (ACE), premenstrual syndrome (PMS), and current psychological stressors.

Methods

Using the Bio-Plex Pro human cytokine 27-plex test kit, we assayed M1 macrophage, T helper (Th)-1, Th-2, Th-17, growth factor, chemokine, and T cell growth immune profiles as well as indicators of the immune inflammatory response system (IRS) and compensatory immunoregulatory system (CIRS) in 120 pregnant females in the early (<16 weeks) and late (>24 weeks) pregnancy. The Edinburgh Postnatal Depression Scale (EPDS) was used to assess severity of antenatal depres

SUBMITTER: Maes M 

PROVIDER: S-EPMC10216549 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature