COVID-19: A Possible Contribution of the MAPK Pathway.

ABSTRACT:

Background

COVID-19 is characterized by an uncontrolled inflammatory response with high pro-inflammatory cytokine production through the activation of intracellular pathways, such as mitogen-activated protein kinase (MAPK). Viruses are able to exploit the MAPK pathway to their advantage; this pathway relevance to severe COVID-19 is poorly described. The aim of this study was to quantify biomarkers involved in the MAPK pathway and to clarify its possible role in affecting some COVID-19-related clinical features.

Methods

H-RAS, C-RAF, MAPK1, MAPK2, and ERK were quantified through ELISA, and genetic polymorphisms were evaluated through real-time PCR.

Results

We prospectively recruited 201 individuals (158 positive and 43 negative for SARS-CoV-2): 35 were male, and their

SUBMITTER: Cusato J 

PROVIDER: S-EPMC10216575 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature