The Role of Regulatory T Cells in the Onset and Progression of Primary Sjogren’s Syndrome

ABSTRACT: Regulatory T cells (Tregs) play a key role in maintaining immune balance and regulating the loss of self-tolerance mechanisms in various autoimmune diseases, including primary Sjögren’s syndrome (pSS). With the development of pSS primarily in the exocrine glands, lymphocytic infiltration occurs in the early stages, mainly due to activated CD4+ T cells. Subsequently, in the absence of rational therapy, patients develop ectopic lymphoid structures and lymphomas. While the suppression of autoactivated CD4+ T cells is involved in the pathological process, the main role belongs to Tregs, making them a target for research and possible regenerative therapy. However, the available information about their role in the onset and progression of this disease seems unsystematized and, in certain aspects

SUBMITTER: Blinova V 

PROVIDER: S-EPMC10216593 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature