Strain-Dependent Morphology of Reactive Astrocytes in Human- and Animal-Vole-Adapted Prions.

ABSTRACT: Reactive astrogliosis is one of the pathological hallmarks of prion diseases. Recent studies highlighted the influence of several factors on the astrocyte phenotype in prion diseases, including the brain region involved, the genotype backgrounds of the host, and the prion strain. Elucidating the influence of prion strains on the astrocyte phenotype may provide crucial insights for developing therapeutic strategies. Here, we investigated the relationship between prion strains and astrocyte phenotype in six human- and animal-vole-adapted strains characterized by distinctive neuropathological features. In particular, we compared astrocyte morphology and astrocyte-associated PrP^Sc deposition among strains in the same brain region, the mediodorsal thalamic nucleus (MDTN). Astrogliosi

SUBMITTER: Bruno R 

PROVIDER: S-EPMC10216604 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature