Sex-Specific Associations of <i>MDM2</i> and <i>MDM4</i> Variants with Risk of Multiple Primary Melanomas and Melanoma Survival in Non-Hispanic Whites.

ABSTRACT: MDM2-SNP309 (rs2279744), a common genetic modifier of cancer incidence in Li-Fraumeni syndrome, modifies risk, age of onset, or prognosis in a variety of cancers. Melanoma incidence and outcomes vary by sex, and although SNP309 exerts an effect on the estrogen receptor, no consensus exists on its effect on melanoma. MDM2 and MDM4 restrain p53-mediated tumor suppression, independently or together. We investigated SNP309, an a priori MDM4-rs4245739, and two coinherited variants, in a population-based cohort of 3663 primary incident melanomas. Per-allele and per-haplotype (MDM2_SNP309-SNP285; MDM4_rs4245739-rs1563828) odds ratios (OR) for multiple-melanoma were estimated with logistic regression models. Hazard ratios (HR) for melanoma death were estimated with Cox proportional h

SUBMITTER: Ward SV 

PROVIDER: S-EPMC10216616 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature